國家衛生研究院 NHRI:Item 3990099045/7256
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 864694      在线人数 : 286
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/7256


    题名: Human immunodeficiency virus drug development assisted with AlGaN/GaN high electron mobility transistors and binding-site models
    作者: Kang, YW;Lee, GY;Chyi, JI;Hsu, CP;Hsu, YR;Hsu, CH;Huang, YF;Sun, YC;Chen, CC;Chun Hung, S;Ren, F;Andrew Yeh, J;Wang, YL
    贡献者: Division of Medical Engineering Research
    摘要: Human immunodeficiency virus (HIV) Reverse Transcriptase (RT)-immobilized AlGaN/GaN high electron mobility transistors (HEMTs) and binding-site models were used to find out the dissociation constants of the HIV RT-inhibitor complex and the number of the binding sites on RT for the inhibitor, Efavirenz. One binding site on the RT for the inhibitor is predicted and the dissociation constant extracted from the binding-site model is 0.212 nM. The AlGaN/GaN HEMTs and the binding-site-models are demonstrated to be good tools to assist drug developments by elucidating the dissociation constants and the number of binding sites, which can largely reduce the cost and time for drug developments.
    日期: 2013-05
    關聯: Applied Physics Letters. 2013 May;102(17):Article number 173704.
    Link to: http://dx.doi.org/10.1063/1.4803916
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0003-6951&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000318553000078
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84877259626
    显示于类别:[許佳賢] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    PB2013052102.pdf867KbAdobe PDF528检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈