國家衛生研究院 NHRI:Item 3990099045/7289
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    题名: Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities
    作者: Lin, CH;Chang, TC;Das, A;Fang, MY;Hung, HC;Hsu, KC;Yang, JM;Von Itzstein, M;Mong, KKT;Hsu, TA;Lin, CC
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: A series of acylguanidine-modified zanamivir analogs were synthesized and their inhibitory activities against the NAs of avian influenza viruses (H1N1 and H3N2) were evaluated. In particular, zanamivir derivative 3j, with a hydrophobic naphthalene substituent, exhibits the best inhibitory activity against group-1 NA with an IC50 of 20 nM.
    日期: 2013-06
    關聯: Organic and Biomolecular Chemistry. 2013 Jun;11(24):3943-3948.
    Link to: http://dx.doi.org/10.1039/c3ob40624e
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1477-0520&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000319670100002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=878683463
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