國家衛生研究院 NHRI:Item 3990099045/7340
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7340


    Title: Genetic variation in the NOC gene is associated with body mass index in Chinese subjects
    Authors: Chang, YC;Chiu, YF;Liu, PH;Hee, SW;Chang, TJ;Jiang, YD;Lee, WJ;Lee, PC;Kao, HY;Hwang, JJ;Chuang, LM
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: Circadian clock genes are critical regulators of energy homeostasis and metabolism. However, whether variation in the circadian genes is associated with metabolic phenotypes in humans remains to be explored. In this study, we systemically genotyped 20 tag single nucleotide polymorphisms (SNPs) in 8 candidate genes involved in circadian clock, including CLOCK, BMAL1(ARNTL), PER1, PER2, CRY1, CRY2, CSNK1E,, and NOC(CCRN4L) in 1,510 non-diabetic Chinese subjects in Taipei and Yunlin populations in Taiwan. Their associations with metabolic phenotypes were analyzed. We found that genetic variation in the NOC gene, rs9684900 was associated with body mass index (BMI) (P = 0.0016, Bonferroni corrected P = 0.032). Another variant, rs135764 in the CSNK1E gene was associated with fasting glucose (P = 0.0023, Bonferroni corrected P = 0.046). These associations were consistent in both Taipei and Yunlin populations. Significant epistatic and joint effects between SNPs on BMI and related phenotypes were observed. Furthermore, NOC mRNA levels in human abdominal adipose tissue were significantly increased in obese subjects compared to non-obese controls. Conclusion:Genetic variation in the NOC gene is associated with BMI in Chinese subjects.
    Date: 2013-07-26
    Relation: PLoS ONE. 2013 Jul 26;8(7):Article number e69622.
    Link to: http://dx.doi.org/10.1371/journal.pone.0069622
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000322838900063
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84880819646
    Appears in Collections:[Yen-Feng Chiu] Periodical Articles

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