國家衛生研究院 NHRI:Item 3990099045/7345

NHRI > Institute of Biotechnology and Pharmaceutical Research > Shiow-Ju Lee > Conference Papers/Meeting Abstract > Item 3990099045/7345

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7345

Title:	Exploration of the role of tylophorine E ring in anti-Coronavirus activity-Tylophorine derived dibenzoquinolines impart multi-biological activities as orally active agents
Authors:	Lee, YZ;Yang, CW;Hsu, HY;Qiu, YQ;Yeh, TK;Chao, YS;Lee, SJ
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	Tylophorine compounds, phenanthroindolizidines and phenanthroquinolizidines, posses multiple potent biological activities including anti-cancer, anti-inflammation, and anti-coronaviruses. In order to explore more classes of tylophorine derivatives for more drug-like compounds, herein we investigate the role of tylophorine E ring in the biological activities through synthesis of a series of compounds with the modification at the E ring either by increasing the C-number or un-cyclizing the E ring and forming different N-substitutes. We have obtained potent derivatives possessing anti-coronavirus activity in terms of anti-TGEV and anti-MHV replication. In addition, the most potent dibenzoquinoline showed improved solubility, in vivo efficacy, and bioavailability as an orally active agent as well as did not showed significant neurotoxicity. The relations of structure and activity of these N-substitutes were analyzed.
Date:	2013-04-13
Relation:	FASEB Journal. 2013 Apr 13;27:lb71.
Link to:	http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/lb71
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0892-6638&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000319883500410
Appears in Collections:	[Shiow-Ju Lee] Conference Papers/Meeting Abstract [Yu-Sheng Chao(2002-2013)] Conference Papers/Meeting Abstract [Teng-Kuang Yeh] Conference Papers/Meeting Abstract

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