國家衛生研究院 NHRI:Item 3990099045/7351
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 917120      線上人數 : 1500
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/7351


    題名: Identification of a quinone compound inhibits human glutaminase activity and induces autophagy in carcinoma cells
    作者: Lee, SJ;Lee, YZ;Hsu, HY;Chang, HY;Chen, IS;Chao, YS
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Natural product sources recently have been applied to discover drugs for being developed to treat cancer, immunosuppressive disorders, resistant bacteria and viruses. In many instances, the disease targeted natural products serve as tools to unravel the cellular molecular targets and pathways in the disease processes and thus facilitate further development. Here, we identified a natural quinone compound that inhibited human kidney glutaminase activity and the cell growth and proliferation of lung carcinoma A549 and hepatoma HepG2 as well as blocked the anchorage-independent colony formation of HepG2. Autophagy but not apoptosis was found in A549 and HepG2 cells treated with the natural quinone compound. Further investigation demonstrated the natural quinone compound inhibiting glutaminase activity and conceivably depleting the cellular nutrient and energy to induce autophagy for anti-cancer activity.
    日期: 2013-04
    關聯: FASEB Journal. 2013 Apr;27:lb70.
    Link to: http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/lb70
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0892-6638&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000319883503140
    顯示於類別:[李秀珠] 會議論文/會議摘要
    [趙宇生(2002-2013)] 會議論文/會議摘要

    文件中的檔案:

    沒有與此文件相關的檔案.



    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋