國家衛生研究院 NHRI:Item 3990099045/7380
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7380


    Title: Brain signature characterizing the body-brain-mind axis of transsexuals
    Authors: Ku, HL;Lin, CS;Chao, HT;Tu, PC;Li, CT;Cheng, CM;Su, TP;Lee, YC;Hsieh, JC
    Contributors: Center for Neuropsychiatric Research
    Abstract: Individuals with gender identity disorder (GID), who are commonly referred to as transsexuals (TXs), are afflicted by negative psychosocial stressors. Central to the psychological complex of TXs is the conviction of belonging to the opposite sex. Neuroanatomical and functional brain imaging studies have demonstrated that the GID is associated with brain alterations. In this study, we found that TXs identify, when viewing male-female couples in erotic or non-erotic (“neutral”) interactions, with the couple member of the desired gender in both situations. By means of functional magnetic resonance imaging, we found that the TXs, as opposed to controls (CONs), displayed an increased functional connectivity between the ventral tegmental area, which is associated with dimorphic genital representation, and anterior cingulate cortex subregions, which play a key role in social exclusion, conflict monitoring and punishment adjustment. The neural connectivity pattern suggests a brain signature of the psychosocial distress for the gender-sex incongruity of TXs.
    Date: 2013-07-26
    Relation: PLoS ONE. 2013 Jul 26;8(7):Article number e70808.
    Link to: http://dx.doi.org/10.1371/journal.pone.0070808
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000322838900176
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84880787632
    Appears in Collections:[Others] Periodical Articles

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