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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7383


    Title: Hepatitis C Virus infection influences the S-methadone metabolite plasma concentration
    Authors: Wu, SL;Wang, SC;Tsou, HH;Kuo, HW;Ho, IK;Liu, SW;Hsu, YT;Chang, YS;Liu, YL
    Contributors: Center for Neuropsychiatric Research;Division of Biostatistics and Bioinformatics
    Abstract: Background and Objectives:Heroin-dependent patients typically contract hepatitis C virus (HCV) at a disproportionately high level due to needle exchange. The liver is the primary target organ of HCV infection and also the main organ responsible for drug metabolism. Methadone maintenance treatment (MMT) is a major treatment regimen for opioid dependence. HCV infection may affect methadone metabolism but this has rarely been studied. In our current study, we aimed to test the hypothesis that HCV may influence the methadone dosage and its plasma metabolite concentrations in a MMT cohort from Taiwan. Methods:A total of 366 MMT patients were recruited. The levels of plasma hepatitis B virus (HBV), HCV, human immunodeficiency virus (HIV) antibodies (Ab), liver aspartate aminotransferase (AST) and alanine aminotransferase (ALT), as well as methadone and its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpy​rrolidine(EDDP) were measured along with the urine morphine concentration and amphetamine screening. Results:Of the 352 subjects in our cohort with HCV test records, 95% were found to be positive for plasma anti-HCV antibody. The liver functional parameters of AST (Wilcoxon Rank-Sum test, P = 0.02) and ALT (Wilcoxon Rank-Sum test, P = 0.04), the plasma methadone concentrations (Wilcoxon Rank-Sum test, P = 0.043) and the R-enantiomer of methadone concentrations (Wilcoxon Rank-Sum test, P = 0.032) were significantly higher in the HCV antibody-positive subjects than in the HCV antibody-negative patients, but not the S-EDDP/methadone dose ratio. The HCV levels correlated with the methadone dose (β= 14.65 and 14.13; P = 0.029 and 0.03) and the S-EDDP/methadone dose ratio ( β = −0.41 and −0.40; P = 0.00084 and 0.002) in both univariate and multivariate regression analyses. Conclusions:We conclude that HCV may influence the methadone dose and plasma S-EDDP/methadone dose ratio in MMT patients in this preliminary study.
    Date: 2013-07-23
    Relation: PLoS ONE. 2013 Jul 23;8(7):Article number e69310.
    Link to: http://dx.doi.org/10.1371/journal.pone.0069310
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000325211000100
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84880709358
    Appears in Collections:[劉玉麗] 期刊論文
    [何英剛(2006-2011)] 期刊論文
    [王聲昌] 期刊論文
    [鄒小蕙] 期刊論文

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