國家衛生研究院 NHRI:Item 3990099045/7440

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7440

Title:	Polymorphisms of genes on the ethanol metabolizing pathway and risk of head and neck cancer
Authors:	Chang, JS;Hsiao, J;Wong, T;Tsai, S;Ou, C;Lo, H;Huang, C;Lee, W;Chen, K;Huang, J;Wang, Y;Weng, Y;Yang, H
Contributors:	National Institute of Cancer Research
Abstract:	Head and neck cancer (HNC), including cancers of the oral cavity, pharynx, and larynx, is the ﬁfth most common cancer in the world. One of the major risk factors of HNC is alcohol drinking; however, most alcohol drinkers do not develop HNC, suggesting a role of genetics. The current study recruited 133 incident cases of HNC and 128 sex and age matched controls from the department of otolaryngology and department of stomatology. Data on alcohol drinking were ascertained through in-person interview. Twenty-seven functional and tag single nucleotide polymorphisms (SNPs) of ﬁ ve alcohol metabolizing genes (ADH1B, ADH1C, ADH4, ADH7, and ALDH2) were genotyped. Single SNP analysis, haplotype analysis, and gene-environment interaction analysis were performed using unconditional logistic regression adjusted for age, gender, and betel-quid chewing. Single SNP and haplotype analyses did not show any statistically signi ﬁ cant (P < 0.05) association with HNC risk. Three SNPs (ADH1B rs1229984, ADH1C rs3762896, and ADH7 rs971074) showed a signi ﬁcant interaction with alcohol drinking to in ﬂ uence HNC risk. Combining the three SNPs, daily alcohol drinking increased HNC risk among those with <2 variant alleles [odds ratio (OR) = 2.4, 95% con ﬁ dence interval (CI): 1.1-5.2] but not among those with two or more variant alleles [OR =1.2, 95% CI: 0.5-3.2]. The current study indicates that polymorphisms of alcohol metabolizing genes may modify the risk of HNC due to alcohol drinking.
Date:	2012-06
Relation:	American Journal of Epidemiology. 2012 Jun;175(Suppl.11):S62.
Link to:	http://dx.doi.org/10.1093/aje/kws258
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0002-9262&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000322831400242
Appears in Collections:	[Jeffrey Shu-Ming] Conference Papers/Meeting Abstract

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