國家衛生研究院 NHRI:Item 3990099045/7455
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7455


    Title: Caged Pt nanoclusters exhibiting corrodibility to exert tumor-inside activation for anticancer chemotherapeutics
    Authors: Chien, CT;Yan, JY;Chiu, WC;Wu, TH;Liu, CY;Lin, SY
    Contributors: Center for Nanomedicine Research
    Abstract: We report on caged Pt nanoclusters that are able to exert tumor-inside activation for anticancer chemotherapeutics and to minimize systemic toxicity. By shrinking the Pt size to 1 nm, it possesses corrodibility for dissolution in weakly acidic organelles to release toxic Pt ions. The therapeutic effect in exerting tumor-inside activation is confirmed in vivo by post-modifying a pH-cleavable PEG corona and mixing it with a tumor-homing peptide for tumour suppression.
    Date: 2013-09
    Relation: Advanced Materials. 2013 Sep;25(36):5067-5073.
    Link to: http://dx.doi.org/10.1002/adma.201302363
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0935-9648&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000327686700009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84884910540
    Appears in Collections:[Shu-Yi Lin] Periodical Articles

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