國家衛生研究院 NHRI:Item 3990099045/7494
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    题名: Longitudinal trajectory of vitamin D status from birth to early childhood in The development of food sensitization
    作者: Liu, X;Arguelles, L;Zhou, Y;Wang, G;Chen, Q;Tsai, HJ;Hong, X;Liu, R;Price, HE;Pearson, C;Apollon, S;Cruz, N;Schleimer, R;Langman, CB;Pongracic, JA;Wang, X
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Background:Increasing evidence supports The immunomodulatory effect of vitamin D on allergic diseases. The combined role of prenatal and postnatal vitamin D status in The development of food sensitization (FS) and food allergy remains understudied.Methods:Plasma 25-hydroxyvitamin D (25(OH)D) levels of 460 children in The Boston Birth Cohort (BBC) were measured at birth and early childhood, and The subjects were genotyped for rs2243250 (C-590T) in The IL4 gene. We defined FS as specific IgE levels of ≥0.35 kUA/l to any of eight common food allergens; we defined persistently low vitamin D status as cord blood 25(OH)D <11 ng/ml and postnatal 25(OH)D <30 ng/ml.Results:We observed a moderate correlation between cord blood 25(OH)D at birth and venous blood 25(OH)D measured at 2-3 y (r = 0.63), but a weak correlation at <1 y (r = 0.28). There was no association between low vitamin D status and FS at any single time point alone. However, in combination, persistence of low vitamin D status at birth and in early childhood increased The risk of FS (odds ratio (OR) = 2.03, 95% confidence interval (CI): 1.02-4.04), particularly among children carrying The C allele of rs2243250 (OR = 3.23, 95% CI: 1.37-7.60).Conclusion: Prenatal and early postnatal vitamin D levels, along with individual genetic susceptibility, should be considered in assessing The role of vitamin D in The development of FS and food allergy.
    日期: 2013-09
    關聯: Pediatric Research. 2013 Sep;74(3):321-326.
    Link to: http://dx.doi.org/10.1038/pr.2013.110
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0031-3998&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000324608600012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84883714863
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