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DBPR116, a prodrug of BPRMU191, in ...
Discovery of a mu-opioid receptor m...
Development of a humanized antibody...
Discovery of dual MER/AXL kinase in...
Discovery of a long half-life AURKA...
A dual nociceptin and mu opioid rec...
Discovery of tetrasubstituted thiop...
Development of furanopyrimidine-bas...
2,6-Difluorobenzamide derivatives a...
Protective effect of CXCR4 antagoni...
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2024-10-29
DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration
Journal of Medicinal Chemistry. 2024 Oct 29;Article in Press.
2024-07-17
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia
Cell Chemical Biology. 2024 Jul 17;Article in Press.
2024-07-04
Development of a humanized antibody targeting extracellular HSP90alpha to suppress endothelial-mesenchymal transition-enhanced tumor growth of pancreatic adenocarcinoma cells
Cells. 2024 Jul 04;13(13):Article number 1146.
2024-06-24
Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment
Journal of Medicinal Chemistry. 2024 Jun 24;Article in Press.
2024-06-01
Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus
Molecular Cancer Therapeutics. 2024 Jun 01;23(6):766-779.
2023-10-05
Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease
European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115583.
2023-10-05
A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects
European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115608.
2023-02-07
Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer
Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588.
2022-12-05
Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation
European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114728.
2022-12-05
2,6-Difluorobenzamide derivatives as store-operated calcium channel (SOC) inhibitors
European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114773.
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