邻近类别 會議論文/會議摘要 [14/24] 專利 [0/8] 类别统计 近3年内发表的文件:18(15.00%) 含全文笔数:119(99.17%) 文件下载次数统计 下载大于0次:119(100.00%) 下载大于100次:114(95.80%) 全文下载总次数:72588(90.20%) 最后更新时间: 2024-12-01 12:36 上传排行 数据加载中..... 下载排行 数据加载中..... 最近上传 DBPR116, a prodrug of BPRMU191, in ... Discovery of a mu-opioid receptor m... Development of a humanized antibody... Discovery of dual MER/AXL kinase in... Discovery of a long half-life AURKA... A dual nociceptin and mu opioid rec... Discovery of tetrasubstituted thiop... Development of furanopyrimidine-bas... 2,6-Difluorobenzamide derivatives a... Protective effect of CXCR4 antagoni...

跳至: (选择年份) 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1985 1980 1975 1970 1960 1950 (选择月份) January February March April May June July August September October November December 或输入年份:

由新到旧排序 由最旧的开始

显示项目51-75 / 120. (共5页) << < 1 2 3 4 5 > >> 每页显示[10|25|50]项目

日期	题名	關聯
2017-01	Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists	European Journal of Medicinal Chemistry. 2017 Jan;126:202-217.
2017-01	A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide	Journal of Medicinal Chemistry. 2017 Jan;60(1):228-247.
2016-12-08	Bromomethylthioindole inspired carbazole hybrids as promising class of anti-MRSA agents	ACS Medicinal Chemistry Letters. 2016 Dec 8;7(12):1191-1196.
2016-12	Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	Oncotarget. 2016 Dec;7(52):86239-86256.
2016-09	Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice	Pharmacological Research. 2016 Sep;111:867-876.
2016-07	In vitro and in vivo studies of a potent capsid-binding inhibitor of enterovirus 71	Journal of Antimicrobial Chemotherapy. 2016 Jul;71(7):1922-1932.
2016-05	N-Indolylglycosides bearing modifications at the glucose C6-Position as Sodium-Dependent Glucose Co-transporter 2 inhibitors	Bioorganic and Medicinal Chemistry. 2016 May;24(10):2242-2250.
2016-01	2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition	Organic and Biomolecular Chemistry. 2016 Jan;14(2):716-723.
2016-01	Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy	Journal of Medicinal Chemistry. 2016 Jan;59(1):419-430.
2015-10	Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening	Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819.
2015-08	Novel Nrf2/ARE activator, trans-coniferylaldehyde, induces a HO-1-mediated defense mechanism through a dual p38alpha/MAPKAPK-2 and PK-N3 signaling pathway	Chemical Research in Toxicology. 2015 Aug ;28(9):1681-1692.
2015-07	Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations	European Journal of Medicinal Chemistry. 2015 Jul;100:151-161.
2015-01	1-Arylsulfonyl-5-(N-hydroxyacrylamide)tetrahydroquinolines as potent histone deacetylase inhibitors suppressing the growth of prostate cancer cells	European Journal of Medicinal Chemistry. 2015 Jan;89:320-330.
2014-05	Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells	Journal of Medicinal Chemistry. 2014 May;57(10):4009-4022.
2014-04	Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones	European Journal of Medicinal Chemistry. 2014 Apr 22;77(2):306-314.
2014-01-08	Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer	PLoS ONE. 2014 Jan 8;9(1):Article number e83160.
2013-11-13	Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice	Journal of Medicinal Chemistry. 2013 Nov 13;56(24):9920-9933.
2013-11	BPR0C305, an orally active microtubule-disrupting anticancer agent	Anticancer Drugs. 2013 Nov;24(10):1047-1057.
2013-07-08	1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines histone deacetylase inhibitors are potent cytokine release suppressors	ChemBioChem. 2013 Jul 8;14(10):1248-1254.
2013-07-08	Inside Cover: 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines histone deacetylase inhibitors are potent cytokine release suppressors(ChemBioChem 10/2013)	ChemBioChem. 2013 Jul 8;14(10):1150.
2013-07	CYP1A2 genetic polymorphisms are associated with early antidepressant escitalopram metabolism and adverse reactions	Pharmacogenomics. 2013 Jul;14(10):1191-1201.
2013-06	Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)	Bioorganic and Medicinal Chemistry. 2013 Jun;21(11):2856-2867.
2013-02	Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems	Antimicrobial Agents and Chemotherapy. 2013 Feb; 57(2):723-733.
2013-01	3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor	ChemMedChem. 2013 Jan;8(1):136-148.
2012-12-13	Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: Exploration of the role of tylophorine e ring on biological activity	Journal of Medicinal Chemistry. 2012 Dec 13;55(23):10363-10377.

显示项目51-75 / 120. (共5页) << < 1 2 3 4 5 > >> 每页显示[10|25|50]项目