國家衛生研究院 NHRI:Item 3990099045/7515
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    题名: Long-term regeneration and functional recovery of a 15mm critical nerve gap bridged by Tremella fuciformis polysaccharide-immobilized polylactide conduits
    作者: Hsu, SH;Chan, SH;Weng, CT;Yang, SH;Jiang, CF
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Novel peripheral nerve conduits containing the negatively charged Tremella fuciformis polysaccharide (TF) were prepared, and their efficacy in bridging a critical nerve gap was evaluated. The conduits were made of poly(D, L-lactide) (PLA) with asymmetric microporous structure. TF was immobilized on the lumen surface of the nerve conduits after open air plasma activation. The TF-modified surface was characterized by the attenuated total reflection Fourier-transformed infrared spectroscopy and the scanning electron microscopy. TF modification was found to enhance the neurotrophic gene expression of C6 glioma cells in vitro. TF-modified PLA nerve conduits were tested for their ability to bridge a 15mm gap of rat sciatic nerve. Nerve regeneration was monitored by the magnetic resonance imaging. Results showed that TF immobilization promoted the nerve connection in 6 weeks. The functional recovery in animals receiving TF-immobilized conduits was greater than in those receiving the bare conduits during an 8-month period. The degree of functional recovery reached similar to 90% after 8 months in the group of TF-immobilized conduits.
    日期: 2013-06
    關聯: Evidence-based Complementary and Alternative Medicine. 2013 Jun;2013:Article number 959261.
    Link to: http://dx.doi.org/10.1155/2013/959261
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000323964000001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84884223633
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