國家衛生研究院 NHRI:Item 3990099045/7525
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 922196      線上人數 : 1374
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/7525


    題名: Zinc-dependent interaction between JAB1 and pre-S2 mutant large surface antigen of hepatitis B virus and its implication for viral hepatocarcinogenesis
    作者: Hsu, JL;Chuang, WJ;Su, IJ;Gui, WJ;Chang, YY;Lee, YP;Ai, YL;Chuang, DT;Huang, W
    貢獻者: Division of Infectious Diseases
    摘要: Chronic hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma (HCC) worldwide. The pre-S2 mutant large HBV surface (Delta2 LHBS) protein, which contains an in-frame deletion of approximately 17 amino acids in LHBS, is highly associated with risks and prognoses of HBV-induced HCC. It was previously reported that Delta2 LHBS interacts with the Jun activation domain-binding protein 1 (JAB1), a zinc metalloprotease. This promotes the degradation of the cell cycle regulator p27Kip1, and is believed to be the major mechanism for Delta2 LHBS-induced HCC. In this study it was found that the interaction between JAB1 and Delta2 LHBS is facilitated by divalent metal Zn2+ ions. The binding of JAB1 to Delta2 LHBS requires the JAB1/CSN5 MPN metalloenzyme (JAMM) motif and residue H138 that binds to Zn2+ ions in JAB1. Isothermal titration calorimetry showed that Delta2 LHBS binds directly to Zn2+ ions in a two-site binding mode. Residues H71 and H116 in Delta2 LHBS, which also contact Zn2+ ions, are too indispensable for Delta2 LHBS-mediated p27Kip1 degradation in human HuH7 cells. These results suggest that developing drugs that interrupt interactions between Delta2 LHBS and JAB1 can be potentially used to mitigate Delta2 LHBS-associated risks for HCC.
    日期: 2013-12
    關聯: Journal of Virology. 2013 Dec;87(23):12675-12684.
    Link to: http://dx.doi.org/10.1128/jvi.01497-13
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-538X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000327183800017
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84887208273
    顯示於類別:[蘇益仁(2002-2015)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB24049181.pdf1643KbAdobe PDF394檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋