國家衛生研究院 NHRI:Item 3990099045/7530
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    题名: Sex differences in opioid analgesia and addiction: Interactions among opioid receptors and estrogen receptors
    作者: Lee, CWS;Ho, IK
    贡献者: Center for Neuropsychiatric Research
    摘要: Opioids are widely used as the pain reliever and also notorious for being addictive drugs. Sex differences in the opioid analgesia and addiction have been reported and investigated in human subjects and animal models. Yet, the molecular mechanism underlying the differences between males and females is still unclear. Here, we reviewed the literature describing the sex differences in analgesic responses and addiction liabilities to clinically relevant opioids. The reported interactions among opioids, estrogens, opioid receptors, and estrogen receptors are also evaluated. We postulate that the sex differences partly originated from the crosstalk among the estrogen and opioid receptors when stimulated by the exogenous opioids, possibly through common secondary messengers and the downstream gene transcriptional regulators.
    日期: 2013-09
    關聯: Molecular Pain. 2013 Sep;9:Article number 45.
    Link to: http://dx.doi.org/10.1186/1744-8069-9-45
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1744-8069&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000324277300001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84883529415
    显示于类别:[何英剛(2006-2011)] 期刊論文

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