國家衛生研究院 NHRI:Item 3990099045/7540
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    题名: STMN1 overexpression as a poor prognostic factor in patients with Nasopharyngeal Carcinoma
    作者: Lee, S;Lin, L;Shiue, Y;Lin, C
    贡献者: National Institute of Cancer Research
    摘要: Purpose/Objective(s): Despite the advances in diagnostic imaging and treatment modalities, the risk stratification and final outcomes in patients with nasopharyngeal carcinomas (NPC) still remain suboptimal. Through data mining from published transcriptomic database, STMN1 was first identified as a differentially upregulated gene in NPC tissues, which encodes stathmin implicating cell division via regulation of the microtubule filament system. Given the roles of STMN1 expression in NPC has not been systemic evaluated; we explored the significance of STMN1 immunoexpression status in a well-defined cohort of NPC patients. Materials/Methods: STMN1 immunohistochemistry was retrospectively performed and analyzed using H-score method for biopsy specimens from 124 NPC patients who received standard treatment without distant metastasis at initial diagnosis. Those cases with H-score larger than the median value were construed as featuring STMN1 overexpression. The results were correlated with the clinicopathological variables, diseasespecific survival (DSS), distant metastasis-free survival (DMFS), and local recurrence-free survival (LRFS). Results: STMN1 overexpression was significantly associated with primary tumor status (p Z 0.003) and AJCC stages III-IV (p Z 0.006) and univariately predictive of adverse outcomes for DSS (pZ0.0001), DMFS (p Z 0.0004), and LRFS (p Z 0.0009). In multivariate comparisons, STMN1 overexpression still remained prognostically independent to portend worse DSS (pZ0.001, hazard ratioZ2.530), DMFS (pZ0.003, hazard ratio Z 2.541), and LRFS (p Z 0.006, hazard ratio Z 2.660) together with advanced AJCC stages III-IV. Conclusions: STMN1 expression is upregulated in a subset of NPCs and its increased immunoexpression significantly correlated with advanced stages and tumor aggressiveness, justifying the potentiality of STMN1 as a prognostic biomarker and a novel therapeutic target of NPC.
    日期: 2013-10
    關聯: International Journal of Radiation Oncology Biology Physics. 2013 Oct;87(2, Supple. 1):S666-S667.
    Link to: http://dx.doi.org/10.1016/j.ijrobp.2013.06.1766
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0360-3016&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000324503602412
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