國家衛生研究院 NHRI:Item 3990099045/7545
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7545


    Title: pH-responsive polymeric micelles with core-shell-corona architectures as intracellular anti-cancer drug carriers
    Authors: Bastakoti, BP;Liao, SH;Inoue, M;Yusa, SI;Imura, M;Nakashima, K;Wu, KCW;Yamauchi, Y
    Contributors: Division of Medical Engineering Research
    Abstract: Polymeric micelles with core-shell-corona nanoarchitecture were designed for intracellular therapeutic anti-cancer drug carriers. Poly(styrene-b-acrylic acid-b-ethylene glycol) (PS-b-PAA-b-PEG) asymmetric triblock copolymer underwent self-assembly in aqueous solution to form spherical micelles with hydrophobic PS core, anionic PAA shell and hydrophilic PEG corona. The anti-cancer drug (doxorubicin, DOX) was successfully incorporated into the polymeric micelles. The in vitro release experiment confirmed that the release of DOX from the micelles was inhibited at pH 7.4. In contrast, an accelerated release of DOX was observed at mildly acidic conditions such as pH 4.5. The excellent biocompatibility of our PS-b-PAA-b-PEG-based micelles made the synthesized nano-carrier best suited for the delivery of anti-cancer drugs.
    Date: 2013-08
    Relation: Science and Technology of Advanced Materials. 2013 Aug;14(4):Article number 044402.
    Link to: http://dx.doi.org/10.1088/1468-6996/14/4/044402
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1468-6996&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000323882000005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84884794462
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