國家衛生研究院 NHRI:Item 3990099045/7570
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 911502      線上人數 : 933
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/7570


    題名: Kinase-focused library: Design and synthesis of pyrimidines derivatives bearing amino substituents using high throughput parallel synthesis
    作者: Wang, WC;Hsieh, HP
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Pyrimidine derivatives bearing amino substituents have been of multifold biological and pharmacological interest. In order to speed up lead identification for drug discovery, the application of high throughput parallel synthesis (HTPS) has become an important target. It is also well known that SNAr reaction has become a useful and efficient synthetic protocol. Herein, a focused library of pyrimidine derivatives was rapidly synthesized in parallel reactor via SNAr displacement and progress of all reactions was monitored by UPLC and LCMS. All library compounds were further screened for kinase activities leading to the identification of interest hit.
    日期: 2013-04-07
    關聯: Abstracts of Papers - American Chemical Society. 2013 Apr 7;245:Article number 298-MEDI
    Link to: http://abstracts.acs.org/chem/245nm/program/view.php?pub_num=298&par=MEDI
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000324303602317
    顯示於類別:[謝興邦] 會議論文/會議摘要
    [王文傑] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000324303602317.pdf274KbAdobe PDF535檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋