國家衛生研究院 NHRI:Item 3990099045/7583

NHRI > National Institute of Infectious Diseases and Vaccinology > Shih-Jen Liu > Periodical Articles > Item 3990099045/7583

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7583

Title:	Increased IL-8 and IL-1beta in the bile of acute cholecystitis patients
Other Titles:	Increased IL-8 and IL-1β in the bile of acute cholecystitis patients
Authors:	Su, PY;Liu, SJ;Chen, YH;Wu, SS;Chen, YL;Ke, JR;Peng, CY;Sher, YP
Contributors:	Division of Vaccine Research and Development
Abstract:	AbstractBackground Acute cholecystitis is inflammation of the gallbladder, and a delayed diagnosis of this condition increases the incidence of patient complications and mortality. Although proinflammatory cytokines are reported to be critical mediators in hepatobiliary disease, little is known regarding the biliary cytokine profile in patients with acute cholecystitis. Method Bile samples were collected from 13 patients with acute cholecystitis who underwent cholecystectomy and 16 healthy adults who underwent cholecystectomy as part of liver donation for transplant. Cytometric bead array immunoassays were performed to measure the levels of proinflammatory cytokines, including IL-8, IL-1β, IL-6, IL-10, TNF, and IL-12p70, in the bile samples. Results We found that biliary IL-8, IL-1β, and IL-6 levels in acute cholecystitis patients were significantly higher than those in healthy adults. A sequential measurement of biliary proinflammatory cytokines showed that IL-8 and IL-1β remained at significantly high levels and that this trend continued for approximately 4–6 days, whereas the IL-6 level varied. Conclusions Biliary IL-8 and IL-1β, but not IL-6, could serve as constant and reliable indicators for patients with acute cholecystitis. Because classical symptoms and blood tests are frequently underestimated or untypical in unconscious and elderly patients, these biliary biomarkers are valuable as a complement to current diagnostic criteria for correct diagnosis of acute cholecystitis.
Date:	2013-12
Relation:	BioMedicine. 2013 Dec;3(4):181-185.
Link to:	http://dx.doi.org/10.1016/j.biomed.2013.08.001
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84888863220
Appears in Collections:	[Shih-Jen Liu] Periodical Articles

Files in This Item:

File	Description	Size	Format
SDO2211802013000739.pdf		727Kb	Adobe PDF	433	View/Open

Loading...