國家衛生研究院 NHRI:Item 3990099045/7597
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    題名: Treatment of methamphetamine abuse: An antibody-based immunotherapy approach
    作者: Chen, YH;Wu, KL;Tsai, HM;Chen, CH
    貢獻者: Center for Neuropsychiatric Research
    摘要: Methamphetamine is a highly addictive psychostimulant with tens of millions of abusers around the world. There is no effective or approved medication for treating an addiction to it. Monoclonal antibodies with a high affinity for methamphetamine have the potential to sequester the drug in the vascular compartment and reduce entry into the brain, thereby acting as peripheral pharmacokinetic antagonists without inducing adverse effects on neurons. However, to maintain the antibodies at an effective level, repeated administration is required, which would be expensive and problematic for patient compliance. In this study, we intended to investigate whether using a recombinant adeno-associated virus-mediated gene transfer technique can be an effective approach to achieve long-term expression of anti-methamphetamine monoclonal antibodies in mouse models. We generated a recombinant adeno-associated virus vector encoding the heavy and light chains of an anti-methamphetamine monoclonal antibody, which was constructed in a single open reading frame and linked with a 2A self-processing sequence. In the context of virus-mediated gene transfer, the expression of full-length and functional monoclonal antibodies was successfully demonstrated in vitro and in vivo. Further investigations are ongoing concerning dose optimization, longterm expression, and protection from methamphetamine challenge in mouse models.
    日期: 2013-12
    關聯: Journal of Food and Drug Analysis. 2013 Dec;21(4 Suppl.):S82-S86.
    Link to: http://dx.doi.org/10.1016/j.jfda.2013.09.040
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1021-9498&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000329422800024
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84897022851
    顯示於類別:[陳嘉祥(2009-2013)] 期刊論文

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