國家衛生研究院 NHRI:Item 3990099045/7623
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 915535      在线人数 : 1269
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/7623


    题名: Common variants associated with plasma triglycerides and risk for coronary artery disease
    作者: Do, R;Willer, CJ;Schmidt, EM;Sengupta, S;Gao, C;Peloso, GM;Gustafsson, S;Kanoni, S;Ganna, A;Chen, J;Buchkovich, ML;Mora, S;Beckmann, JS;Bragg-Gresham, JL;Chang, HY;Demirkan, A;Den Hertog, HM;Donnelly, LA;Ehret, GB;Esko, T;Feitosa, MF;Ferreira, T;Fischer, K;Fontanillas, P;Fraser, RM;Freitag, DF;Gurdasani, D;Heikkilä, K;Hyppönen, E;Isaacs, A;Jackson, AU;Johansson, A;Johnson, T;Kaakinen, M;Kettunen, J;Kleber, ME;Li, X;Luan, J;Lyytikäinen, LP;Magnusson, PKE;Mangino, M;Mihailov, E;Montasser, ME;Müller-Nurasyid, M;Nolte, IM;O'Connell, JR;Palmer, CD;Perola, M;Petersen, AK;Sanna, S;Saxena, R;Service, SK;Shah, S;Shungin, D;Sidore, C;Song, C;Strawbridge, RJ;Surakka, I;Tanaka, T;Teslovich, TM;Thorleifsson, G;Van den Herik, EG;Voight, BF;Volcik, KA;Waite, LL;Wong, A;Wu, Y;Zhang, W;Absher, D;Asiki, G;Barroso, I;Been, LF;Bolton, JL;Bonnycastle, LL;Brambilla, P;Burnett, MS;Cesana, G;Dimitriou, M;Doney, ASF;Döring, A;Elliott, P;Epstein, SE;Eyjolfsson, GI;Gigante, B;Goodarzi, MO;Grallert, H;Gravito, ML;Groves, CJ;Hallmans, G;Hartikainen, AL;Hayward, C;Hernandez, D;Hicks, AA;Holm, H;Hung, YJ;Illig, T;Jones, MR;Kaleebu, P;Kastelein, JJP;Khaw, KT, .;et al.
    贡献者: Division of Health Services and Preventive Medicine;Division of Biostatistics and Bioinformatics
    摘要: Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10−8 for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.
    日期: 2013-10
    關聯: Nature Genetics. 2013 Nov;45(11):1345-1352.
    Link to: http://dx.doi.org/10.1038/ng.2795
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1061-4036&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000326384100015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84887058576
    显示于类别:[張新儀] 期刊論文
    [熊昭] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SCP84884846622.pdf398KbAdobe PDF521检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈