國家衛生研究院 NHRI:Item 3990099045/7629
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 856890      在线人数 : 956
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/7629


    题名: Reference values of total serum IgE and their significance in the diagnosis of allergy in Asian children: PATCH study
    作者: Tu, YL;Tsai, HJ;Chang, SW;Cheng, JH;Huang, JL;Yao, TC;Grp, PS
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Background: Total serum immunoglobulin (IgE) test is usually performed to aid in the diagnosis of allergic diseases. Reference values of total IgE may vary among people of different ethnic backgrounds. This study aimed to establish reference values of total IgE levels in Asian children and to assess the significance of these values in the diagnosis of allergic sensitisation and allergic diseases. Methods: A total of 1321 Asian children aged 5– 18 years from the Prediction of Allergies in Taiwanese CHildren (PATCH) study, a population-based cohort, were evaluated for total and specific IgE levels by ImmunoCAP and ImmunoCAP Phadiatop Infant, respectively. Results: The geometric mean total IgE was significantly higher for children with allergic sensitisation than those without (239.5 vs 27.5 kU/l, P < 0.001), and for boys than girls (112.8 vs 74.4 kU/l, P < 0.001). Multivariate regression analysis revealed that allergic sensitisation was the single most important independent variable explaining variability of total IgE levels in this population. The area under the receiver-operator characteristic (ROC) curve of total IgE for diagnosing allergic sensitisation, asthma, allergic rhinitis and atopic dermatitis were 0.92, 0.72, 0.70 and 0.70, respectively. The sensitivity, specificity, and positive (PPV) and negative predictive values (NPV) of total IgE at the opitmal cut-off of 77.7 kU/l on the ROC curve for diagnosing allergic sensitisation were 82.3%, 87.1%, 89.5%, and 78.6%, respectively; whereas the corresponding values using the upper 95% CI of total IgE levels (164.3 kU/l) in children without allergic sensitisation were 61.2%, 95.0%, 94.3%, and 64.6%, respectively. Conclusion: Total serum IgE test discriminates Asian children with and without allergic sensitisation independent of allergic symptoms, with an optimal cutoff of 77.7 kU/l. This study confirms the insufficient diagnostic accuracy of total IgE levels alone to detect allergic diseases.
    日期: 2013-09
    關聯: Allergy. 2013 Sep;68(Suppl. S97):447.
    Link to: http://dx.doi.org/10.1111/all.12251
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000325142904084
    显示于类别:[蔡慧如] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI000325142904084.pdf198KbAdobe PDF381检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈