國家衛生研究院 NHRI:Item 3990099045/7635
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    題名: High-frequency ultrasound imaging to evaluate liver fibrosis progression in rats and Yi Guan Jian herbal therapeutic effects
    作者: Chen, W;Chen, JY;Tung, YT;Chen, HL;Kuo, CW;Chuang, CH;Chong, KY;Mao, FC;Chen, CM
    貢獻者: Center for Nanomedicine Research
    摘要: The animals used in liver fibrosis studies must usually be sacrificed. Ultrasound has been demonstrated to have the ability to diagnose hepatic fibrosis and cirrhosis in experimental small-animal models. However, few studies have used high-frequency ultrasound (HFU, 40 MHz) to monitor changes in the rat liver and other hollow organs longitudinally. In this study, liver fibrosis was induced by administering dimethylnitrosamine (DMN) in SD rats, aged 8 weeks, for three consecutive days per week for up to 4 weeks. A Chinese herbalmedicine Yi Guan Jian (YGJ) was orally administered (1.8 g/kg daily) to DMN-induced liver fibrosis rats for 2 weeks. Compared with the normal control rats, rats treated with DMN for either 2 weeks or 4 weeks had significantly lower body weights, liver indexes and elevation of hydroxyproline, GOT, and GPT contents. YGJ herbal treatment remarkably prevented rats from DMN-induced liver fibrosis. The HFU scoring results among the normal controls, 2-week DMN-treated rats, 4-week DMN-treated rats, and combined 2-week YGJ therapy with 4-week DMN-treated rats also reached statistical significance. Thus, HFU is an accurate tool for the longitudinal analysis of liver fibrosis progression in small-animal models, and the YGJ may be useful in reversing the development of hepatic fibrosis.
    日期: 2013-10
    關聯: Evidence-based Complementary and Alternative Medicine. 2013 Oct;2013:Article number 302325.
    Link to: http://dx.doi.org/10.1155/2013/302325
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000326545600001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84887488675
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