國家衛生研究院 NHRI:Item 3990099045/7646
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    题名: A comparative study of clinical Aeromonas dhakensis and Aeromonas hydrophila isolates in southern Taiwan: A. dhakensis is more predominant and virulent
    作者: Chen, PL;Wu, CJ;Chen, CS;Tsai, PJ;Tang, HJ;Ko, WC
    贡献者: Division of Infectious Diseases
    摘要: Aeromonas dhakensis, often phenotypically identified as A. hydrophila, is an important human pathogen. The present study aimed to compare the clinical and biological features of A. dhakensis and A. hydrophila isolates from human wounds. A total of 80 of Aeromonas wound isolates collected between January 2004 and April 2011 were analyzed. The species was identified by the DNA sequence matching of rpoD and gyrB (or rpoB if necessary). Most of the Aeromonas isolates were identified as A. dhakensis (37, 46.3%), and 13 (16.3%) as A. hydrophila. Both these two species alone can cause severe skin and soft-tissue infections. More A. dhakensis isolates were found in wounds exposed to environmental water (32.4% vs. 0%, P=0.042). More biofilm formation was noted among A. dhakensis isolates (mean OD570, 1.23±0.09 vs. 0.78±0.21, P=0.03). The minimal inhibitory concentrations of ceftriaxone, imipenem, and gentamicin for A. dhakensis isolates were higher (P values <0.0001, 0.04, and 0.01, respectively). The survival rates of Caenorhabditis elegans co-incubated by A. dhakensis from day 1 to day 3 were lower than those of worms infected with A. hydrophila in liquid toxicity assays (all P values <0.01). A. dhakensis isolates exhibited more cytotoxicity, as measured by the released leukocyte lactate dehydrogenase levels in human normal skin fibroblast cell lines (29.6±1.2% vs. 20.6±0.6%, P<0.0001). The cytotoxin gene ast was primarily present in A. hydrophila isolates (100% vs. 2.7%, P<0.0001). In summary, A. dhakensis is the predominant species among Aeromonas wound isolates, and more virulent than A. hydrophila.
    日期: 2014-07
    關聯: Clinical Microbiology and Infection. 2014 Jul;20(7):O428-O434.
    Link to: http://dx.doi.org/10.1111/1469-0691.12456
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1198-743X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000340199000004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84905018680
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