國家衛生研究院 NHRI:Item 3990099045/7715
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7715


    Title: Effects of high-dose phytoestrogens on circulating cellular microparticles and coagulation function in postmenopausal women
    Authors: Cheng, WC;Lo, SC;Tsai, KS;Tu, ST;Wu, JS;Chang, CI;Chen, CL;Shaw, NS;Peng, HY;Wang, SY;Wu, CH;Jan, IS;Hsu, SC;Liu, CW;Lee, LN;Tai, TY
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: Background: Estrogen in hormone replacement therapy causes homeostatic changes. However, little is known regarding the safety of high-dose phytoestrogen on coagulation and hematological parameters in healthy postmenopausal women. This study evaluated the effects of high-dose soy isoflavone (300 mg/day) on blood pressure, hematological parameters, and coagulation functions including circulating microparticles in healthy postmenopausal women. Methods: The original study is a 2-year prospective, double-blind, placebo-controlled study. In total, 431 postmenopausal women (from 3 medical centers) were randomly assigned to receive either high-dose isoflavone or placebo for 2 years. At baseline, 6 months, 1 year, and 2 years after treatment, blood pressure, body weight, liver function tests, hematological parameters, and lipid profiles were measured. The 1st year blood specimens of 85 cases of 144 eligible participants (from one of the three centers) were analyzed as D-dimer, von Willebrand factor antigen, factor VII, plasminogen activator inhibitor type 1, and circulating cellular microparticles, including the measurement of monocyte, platelet, and endothelial microparticles. Results: In the isoflavone group, after 1 year, the changes in liver function tests, hematological parameters, and coagulation tests were not different from those of the control. Triglyceride levels were significantly lower after 6 months of isoflavone treatment than the placebo group, but the difference did not persist after 1 year. Endothelial microparticles increased steadily in both groups during the 1-year period but the trend was not affected by treatment. Conclusion: The results of the present study indicate that high-dose isoflavone treatment (300 mg/day) does not cause hematological abnormalities or activate coagulation factors.
    Date: 2015-08
    Relation: Journal of the Formosan Medical Association. 2015 Aug;114(8):710-716.
    Link to: http://dx.doi.org/10.1016/j.jfma.2013.11.001
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0929-6646&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000369399300007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84940439438
    Appears in Collections:[Tong-Yuan Tai(2003-2005)] Periodical Articles

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