國家衛生研究院 NHRI:Item 3990099045/7719
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    題名: Epidemiology and molecular characterization of macrolide-resistant Streptococcus pyogenes in Taiwan
    作者: Huang, CY;Lai, JF;Huang, IW;Chen, PC;Wang, HY;Shiau, YR;Cheng, YW;Hsieh, LY;Chang, SC;Lauderdale, TL
    貢獻者: Division of Infectious Diseases
    摘要: Our multicenter nationwide surveillance data indicated that erythromycin (ERY)-resistance among Group A Streptococcus (GAS) in Taiwan declined from 53.1% in 1998-2000 to 14.6% in 2002-2004 and 10.7% in 2006-2010 (p <0.01). The present study aimed to assess the epidemiology of GAS in Taiwan and identify factors associated with ERY-resistance. All 127 ERY-resistant (ERY-R) and 128 randomly selected ERY-susceptible (ERY-S) isolates from 1998-2010 were emm typed. ERY-R isolates were also characterized by ERY-resistance phenotype and mechanisms, and pulsed-field gel electrophoresis (PFGE). Multilocus sequence typing was performed on selected ERY-R isolates. The predominant emm types in ERY-R isolates were emm22 (33, 26.0%), emm12 (24, 18.9%), emm4 (21, 16.5%), and emm106 (15, 11.8%). In ERY-S isolates, emm12 (27, 21.9%), emm1 (18, 14.1%), emm106 (16, 12.5%), and emm11 (9, 7.1%) predominated. The most common ERY-resistance phenotype was M (70.9%) with all but one carrying mef(A), followed by cMLSB (26.8%) carrying erm(B) or erm(TR). ERY-R isolates of the emm12-ST36 lineage with the cMLSB phenotype was mostly present before 2004 while emm22-ST46 with the M phenotype predominated in later years. Recovery from respiratory (throat) specimens was an independent factor associated with ERY-resistance. The emm1 and emm11 isolates were significantly associated with ERY-S GAS while emm22 was detected only in ERY-R GAS. In addition, emm106 isolates were prevalent in abscess/pus isolates whereas emm12 isolates were strongly associated with respiratory (throat) origin. In addition to identifying factors associated with ERY-resistance in GAS, our study provides helpful information on the changing GAS epidemiology in Taiwan.
    日期: 2014-02
    關聯: Journal of Clinical Microbiology. 2014 Feb;52(2):508-516.
    Link to: http://dx.doi.org/10.1128/jcm.02383-13
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0095-1137&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000330444200018
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84893067223
    顯示於類別:[楊采菱] 期刊論文

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