國家衛生研究院 NHRI:Item 3990099045/7745
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7745


    Title: Endothelin type A receptor genotype is a determinant of quantitative traits of metabolic syndrome in Asian hypertensive families: A SAPPHIRe study
    Authors: Ho, LT;Hsu, YP;Hsiao, CF;Ting, CT;Shih, KC;Chuang, LM;Masaki, K;Grove, J;Quertermous, T;Juan, CC;Lin, MW;Chiang, SC;Chen, YD
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: Co-heritability of hypertension and insulin resistance (IR) within families not only implies genetic susceptibility may be responsible for these complex traits but also suggests a rational that biological candidate genes for hypertension may serve as markers for features of the metabolic syndrome (MetS). Thus we determined whether the T323C polymorphism (rs5333) of endothelin type A (ETA) receptor, a predominant receptor evoking potent vasoconstrictive action of endothelin-1, contributes to susceptibility to IR-associated hypertension in 1694 subjects of Chinese and Japanese origins. Blood pressures (BPs) and biochemistries were measured. Fasting insulin level, insulin-resistance homeostasis model assessment (HOMAIR) score, and area under curve of insulin concentration (AUCINS) were selected for assessing insulin sensitivity. Genotypes were obtained by methods of polymerase chain reaction-restriction fragment length polymorphism. Foremost findings were that minor allele frequency of the T323C polymorphism was noticeable lower in our overall Asian subjects compared to multi-national population reported in gene database; moreover both the genotypic and allelic frequencies of the polymorphism were significantly different between the two ethnic groups we studied. The genotype distributions at TT/TC/CC were 65, 31, 4% in Chinese and 51, 41, 8% in Japanese, respectively (p < 0.0001). Additionally, carriers of the C homozygote revealed characteristics of IR, namely significantly higher levels of fasting insulin, HOMAIR score, and AUCINS at 29.3, 35.3, and 39.3%, respectively, when compared to their counterparts with TT/TC genotypes in Chinese. Meanwhile, the CC genotype was associated with a higher level of high density lipoprotein cholesterol in Japanese. No association of the polymorphism with BP was observed. This study demonstrated for the first time that T323C polymorphism of ETA receptor gene was associated with an adverse insulin response in Chinese and a favorite atherogenic index in Japanese.
    Date: 2013-11-28
    Relation: Frontiers in Endocrinology. 2013 Nov 28;4:Article number 172.
    Link to: http://dx.doi.org/10.3389/fendo.2013.00172
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1664-2392&DestApp=IC2JCR
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84890254472
    Appears in Collections:[Chin-Fu Hsiao] Periodical Articles

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