國家衛生研究院 NHRI:Item 3990099045/7767
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    題名: Prostaglandin E2 promotes post-infarction cardiomyocyte replenishment by endogenous stem cells
    其他題名: Prostaglandin E-2 promotes post-infarction cardiomyocyte replenishment by endogenous stem cells
    作者: Hsueh, YC;Wu, JMF;Yu, CK;Wu, KK;Hsieh, PCH
    貢獻者: Institute of Cellular and Systems Medicine
    摘要: Although self‐renewal ability of adult mammalian heart has been reported, few pharmacological treatments are known to promote cardiomyocyte regeneration after injury. In this study, we demonstrate that the critical period of stem/progenitor cell‐mediated cardiomyocyte replenishment is initiated within 7 days and saturates on day 10 post‐infarction. Moreover, blocking the inflammatory reaction with COX‐2 inhibitors may also reduce the capability of endogenous stem/progenitor cells to repopulate lost cells. Injection of the COX‐2 product PGE2 enhances cardiomyocyte replenishment in young mice and recovers cell renewal through attenuating TGF‐β1 signaling in aged mice. Further analyses suggest that cardiac stem cells are PGE2‐responsive and that PGE2 may regulate stem cell activity directly through the EP2 receptor or indirectly by modulating its micro‐environment in vivo. Our findings provide evidence that PGE2 holds great potential for cardiac regeneration.
    日期: 2014-04
    關聯: EMBO Molecular Medicine. 2014 Apr;6(4):496-503.
    Link to: http://dx.doi.org/10.1002/emmm.201303687
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1757-4676&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000333742100009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84897406949
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