國家衛生研究院 NHRI:Item 3990099045/7778
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    题名: Profiling eicosanoids in breath condensates of asthmatic and healthy children
    作者: Chen, Lc;Huang, JL;Wu, AIH;Kuo, ML;Huang, SK
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: RATIONALE: Eicosanoids are lipid mediators implicated in the regulation of allergic inflammation responses and have been considered as potentialbiomarkersforasthmaticchildren.Theobjectiveofthisstudywas to investigate profiles of 10 selected eicosanoid metabolites in exhaled breath condensates (EBCs) of children with asthma in comparison to those of healthy children. METHODS: EBCs were from 175 children (aged 9±2.3 years) with stable atopic asthma (58 using inhaled steroids) and 125 healthy controls (10.8±1.2 years).Either high performance liquid chromatography coupled with tandem mass spectrometry (LC/MS) or enzymatic immunoassays (EIA) were used to measure 10 different metabolites. In addition, exhaled nitric oxide levels (FeNO) and bronchial hyperresponsiveness were assessed through a methacholine challenge test (PC 20) in all subjects. RESULTS: Among the ten eicosanoids, the levels of LTB4 (5.71 pg/ml vs0.44 pg/ml; P<0.001), LTE4 (9.13 pg/ml vs 5.38 pg/ml; P<0.001), and PGE2 (13.29 pg/ml vs 6.77pg/ml; P<0.018) were significantly higher inasthmatics than in healthy children, while 11-dehydro TXB2 was significantly less abundant (3.55 pg/ml vs 1.0 pg/ml; P=0.045) in asthmatics.The levels of eicosanoids demonstrated no appreciable relationship to asthma severity. From the fasting lipid profiles, we found a slightly higher level of cholesterol, with all other elements being within the normal range. These parameters discriminated asthmatics from healthy children better than FEV1 , FeNO or PC20. CONCLUSIONS: In the current study, a composite of LTB4,LTE4 and PGE2 levels in EBCs was distinguishable between asthmatic and healthy subjects, suggesting the potential utility of assessing EBC’s eicosanoids as inflammatory markers for childhood asthma.
    日期: 2014-02
    關聯: Journal of Allergy and Clinical Immunology. 2014 Feb;133(2, Suppl.):AB141.
    Link to: http://dx.doi.org/10.1016/j.jaci.2013.12.519
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0091-6749&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000330241300492
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