國家衛生研究院 NHRI:Item 3990099045/7847
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7847


    Title: The association of genetic polymorphisms in the kappa-opioid receptor 1 gene with body weight, alcohol use, and withdrawal symptoms in patients with methadone maintenance
    Other Titles: The association of genetic polymorphisms in the κ-opioid receptor 1 gene with body weight, alcohol use, and withdrawal symptoms in patients with methadone maintenance
    Authors: Wang, SC;Tsou, HH;Chung, RH;Chang, YS;Fang, CP;Chen, CH;Ho, IK;Kuo, HW;Liu, SC;Shih, YH;Wu, HY;Huang, BH;Lin, KM;Chen, AC;Hsiao, CF;Liu, YL
    Contributors: Center for Neuropsychiatric Research;Division of Biostatistics and Bioinformatics;Division of Clinical Trial Statistics
    Abstract: Methadone is a synthetic opioid that binds to the kappa-opioid receptor with a low affinity. This study tested the hypotheses that the genetic polymorphisms in the kappa-opioid receptor 1 (OPRK1) gene region are associated with methadone treatment responses in a Taiwan methadone maintenance treatment (MMT) cohort. Seventeen single nucleotide polymorphisms (SNPs) in OPRK1 were selected and genotyped on DNA of 366 MMT patients. Six SNPs from rs7843965 to rs1051660 (intron 2 to exon 2) were significantly associated with body weight (P < 0.007). A haplotype of 4 SNPs rs7832417-rs16918853-rs702764-rs7817710 (exon 4 to intron 3) was associated with bone or joint aches (P </= 0.004) and with the amount of alcohol use (standard drinks per day; global P < 0.0001). The haplotype rs10958350-rs7016778-rs12675595 was associated with gooseflesh skin (global P < 0.0001), yawning (global P = 0.0001), and restlessness (global P < 0.0001) withdrawal symptoms. The findings suggest that genetic polymorphisms in OPRK1 were associated with the body weight, alcohol use, and opioid withdrawal symptoms in MMT patients.
    Date: 2014-04
    Relation: Journal of Clinical Psychopharmacology. 2014 Apr;34(2):205-211.
    Link to: http://dx.doi.org/10.1097/jcp.0000000000000082
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0271-0749&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000335328000006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84896404655
    Appears in Collections:[Yu-Li Liu] Periodical Articles
    [Keh-Ming Lin(2004-2009)] Periodical Articles
    [Sheng-Chang Wang] Periodical Articles
    [Ing-Kang Ho(2006-2011)] Periodical Articles
    [Ren-Hua Chung] Periodical Articles
    [Hsiao-Hui Sophie Tsou] Periodical Articles
    [Chin-Fu Hsiao] Periodical Articles

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