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http://ir.nhri.org.tw/handle/3990099045/7870
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| Title: | The impact of chronic kidney disease on lipid management and goal attainment in patients with atherosclerosis diseases in Taiwan |
| Authors: | Lin, TH;Chuang, SY;Chu, CY;Lee, WH;Hsu, PC;Su, HM;Li, YH;Fang, CC;Wang, KY;Tseng, WK;Li, AH;Ueng, KC;Hsieh, IC;Huang, LC;Wang, CH;Pan, WH;Yeh, HI;Wu, CC;Yin, WH;Chen, JW |
| Contributors: | Division of Health Services and Preventive Medicine |
| Abstract: | Background: Patients with chronic kidney disease (CKD) is a very high risk cardiovascular disease population and should be treated aggressively. We investigated lipid management in CKD patients with atherosclerosis in Taiwan. Methods: 3057 patients were enrolled in a multi-center study (T-SPARCLE). Lipid goal are defined as total cholesterol (TC) < 160mg/dl, low-density lipoprotein (LDL) <100 mg/dl, high-density lipoprotein (HDL) > 40 mg/dl in men, HDL > 50 mg/dl in women, non-HDL cholesterol < 130mg/dl, and triglyceride < 150 mg/dl. Results: Compared with those without CKD (n=2239), patients with CKD (n=818) had more co-morbidities (hypertension, glucose intolerance, stroke and heart failure) and lower HDL but higher triglyceride levels. Overall 2168 (70.5%) patients received lipid-lowering agents. There was similar equivalent statin potency between CKD and non-CKD groups. The goal attainment is lower in HDL and TG in the CKD group as compared with non-CKD subjects (47.1 vs. 51.9% and 63.2 vs. 68.9% respectively, both p < 0.02). Analysis of sex and CKD interaction on goals attainment showed female CKD subjects had lower non-HDL and TG goals attainment compared with non-CKD males (both p < 0.019). Conclusion: Although presenting with more comorbidities, the CKD population had suboptimal lipid goal attainment rate as compared with the non-CKD population. Further efforts may be required for better lipid control especially on the female CKD subjects. |
| Date: | 2014-02 |
| Relation: | International Journal of Medical Sciences. 2014 Feb 20;11(4):381-388. |
| Link to: | http://dx.doi.org/10.7150/ijms.7069 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1449-1907&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000334609100010 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84896737477 |
| Appears in Collections: | [潘文涵] 期刊論文
[莊紹源] 期刊論文
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| PUB24578616.pdf | | 491Kb | Adobe PDF | 486 | View/Open |
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