國家衛生研究院 NHRI:Item 3990099045/7908
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    题名: Multiplexed immunoglobulin E sensitization in relation to exhaled nitric oxide in a population sample of children
    作者: Yao, TC;Tsai, HJ;Tu, YL;Chang, SW;Hua, MC;Liao, SL;Tsai, MH;Chiu, CY;Lai, SH;Yeh, KW;Huang, JL
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mites (P < 0.001), animals (P = 0.001), cockroaches (P < 0.001), and foods (P = 0.042), and furthermore, between FeNO and the number of sensitizations (all P < 0.05) or the sum of specific IgE (all P ≤ 0.01) against the aforementioned allergen categories. Specifically, sensitization to the following allergens was significantly related to higher FeNO: Dermatophagoides pteronyssinus, Dermatophagoides farina, Blomia tropicalis, cat, German cockroach, Oriental cockroach, codfish, crab, shrimp, and cheese (all P ≤ 0.01). In conclusion, IgE sensitization to mites, pets, cockroaches, seafood, and cheese, respectively, is significantly associated with elevated FeNO levels in a dose-dependent fashion in children. Our results provide new evidence that sensitization to certain food allergens may contribute to prompt inflammation in the airways.
    日期: 2014-05
    關聯: Allergy: European Journal of Allergy and Clinical Immunology. 2014 May;69(5):678-682.
    Link to: http://dx.doi.org/10.1111/all.12378
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000333816900016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84898482279
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