國家衛生研究院 NHRI:Item 3990099045/7957
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    题名: Monitoring and control of inertial cavitation activity for enhancing ultrasound transfection: The SonInCaRe project
    作者: Inserra, C;Labelle, P;Der Loughian, C;Lee, JL;Fouqueray, M;Ngo, J;Poizat, A;Desjouy, C;Munteanu, B;Lo, CW;Vanbelle, C;Rieu, JP;Chen, WS;B?ra, JC
    贡献者: Division of Medical Engineering Research
    摘要: Sonoporation process, at the origin of ultrasound cell transfection, is ruled by the interaction between cells and cavitating bubbles. Due to the stochastic behavior of acoustic cavitation, there exists a need in ensuring a stable state of cavitation within a medium during cell transfection to enhance transfection efficiency and control mortality. The goal of the SonInCaRe project is thus to define a controlled-cavitation device in order to monitor, control and stabilize inertial cavitation activity during cell sonication in real-time. This device, based on a feedback loop acting in real-time, allows ensuring fixed cavitation conditions during a pulsed sonication. Its application to suspended and adherent cells transfection shows better reproducibility compared to the fixed acoustic intensity sonication. The regulation device thus provides a better control of cavitation activity and its bioeffects which are of crucial importance for clinical applications of ultrasound-mediated gene transfection.
    日期: 2014-04
    關聯: IRBM. 2014 Arp;35(2):94-99.
    Link to: http://dx.doi.org/10.1016/j.irbm.2014.02.010
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1959-0318&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000336355400008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84898413632
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