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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/7996


    Title: Plasmid transferability of KPC into a virulent K2 serotype Klebsiella pneumoniae
    Authors: Siu, LK;Huang, D;Chiang, T
    Contributors: Division of Infectious Diseases
    Abstract: BACKGROUND:KPC-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) infections are associated with high mortality; however, their virulence determinants are not well defined.METHODS:We investigated the virulence and plasmid transferability among KPC-containing K. pneumoniae isolates.RESULTS:KPC-2 and -3 were successfully conjugated and retained by a virulent K2 K. pneumoniae recipient isolate. Antimicrobial susceptibility testing showed KPC-2 and -3 donor strains were resistant to more than four classes of antibiotics while the K2 isolate was only initially resistant to ampicillin. After conjugation of KPC-2 and -3, the K2 K. pneumoniae transconjugants became resistant to all beta-lactams. Additionally, the KPC K2 K. pneumoniae transconjugants continued to retain its high serum resistance and murine lethality.CONCLUSIONS:Conjugation and retainment of KPC by virulent K2 K. pneumoniae and the ability of the tranconjugants to maintain its high serum resistance and murine lethality after conjugation was demonstrated in this study. These findings are concerning for the potential of KPC-like genes to disseminate among virulent K. pneumoniae isolates.
    Date: 2014-03-31
    Relation: BMC Infectious Diseases. 2014 Mar 31;14(1):Article number 176.
    Link to: http://dx.doi.org/10.1186/1471-2334-14-176
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1471-2334&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000335470000002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84897551881
    Appears in Collections:[蕭樑基] 期刊論文

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