國家衛生研究院 NHRI:Item 3990099045/8018
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    题名: Dengue 2 virus infection activates autophagy that is favorable for viral replication in mosquito aedes aegypti
    作者: Chen, CC;Tsao, IY;Lu, YC;Shiao, SH;Chen, CH;Tsai, CH
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Autophagy is a catabolic process for the maintenance of cellular homeostasis and is also important in times of stress, including viral infection. Recently we found knockdown of three authophagy genes, ATG5, ATG8 and ATG18, significantly reduced the transcriptional levels and tiers of dengue 2 virus(DENV2) in Ades aegypti. We also found that DENV2 transcription level was significantly reduced after autophagy was blocked by 3 methyladenine or L-asparagine and was significantly enhanced after authophagy was induced by rapamycin. Western blotting analysis also demonstrated that level of the LC3-II, the widely used biomarker of authophagy, was significantly increased in DENV2-infected mosquitoes at 24h post inoculatin(p.i.) and reached the maximum at 48h p.i. Then is gradually declined but remained detectable at 96h p.i. Subsequently, our results suggested that in vector mosquitoes, DENV2 can activate autophagy machinery that is favorable for viral replication.
    日期: 2013-12
    關聯: Pathogens and Global Health. 2013 Dec;107(8):404.
    Link to: http://dx.doi.org/10.1179/2047772413Z.000000000160
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2047-7724&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000335056200015
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