English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 907499      Online Users : 976
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8026


    Title: Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
    Authors: Wen, W;Zheng, W;Okada, Y;Takeuchi, F;Tabara, Y;Hwang, JY;Dorajoo, R;Li, H;Tsai, FJ;Yang, X;He, J;Wu, Y;He, M;Zhang, Y;Liang, J;Guo, X;Sheu, WH;Delahanty, R;Kubo, M;Yamamoto, K;Ohkubo, T;Go, MJ;Liu, JJ;Gan, W;Chen, CC;Gao, Y;Li, S;Lee, NR;Wu, C;Zhou, X;Song, H;Yao, J;Lee, IT;Long, J;Tsunoda, T;Akiyama, K;Takashima, N;Cho, YS;Ong, RT;Lu, L;Chen, CH;Tan, A;Rice, TK;Adair, LS;Gui, L;Allison, M;Lee, WJ;Cai, Q;Isomura, M;Umemura, S;Kim, YJ;Seielstad, M;Hixson, J;Xiang, YB;Isono, M;Kim, BJ;Sim, X;Lu, W;Nabika, T;Lee, J;Lim, WY;Gao, YT;Takayanagi, R;Kang, DH;Wong, TY;Hsiung, CA;Wu, IC;Juang, JM;Shi, J;Choi, BY;Aung, T;Hu, F;Kim, MK;Wang, TD;Shin, MH;Ji, BT;Lee, YH;Young, TL;Shin, DH;Chun, BY;Cho, MC;Han, BG;Hwu, CM;Assimes, TL;Absher, D;Yan, X;Kim, E;Kuo, JZ;Kwon, S;Taylor, KD;Chen, YD;Rotter, JI;Qi, L;Zhu, D;Wu, T;Mohlke, KL;Gu, D, .;et al.
    Contributors: Division of Biostatistics and Bioinformatics;Division of Geriatric Research
    Abstract: Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and approximately 2.5 million genotyped or imputed SNPs among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488 to 47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P=9.29x10-13), ALDH2/MYL2 (rs671, P=3.40x10-11; rs12229654, P=4.56x10-9), ITIH4 (rs2535633, P=1.77x10-10), and NT5C2 (rs11191580, P=3.83x10-8) genes. The association of BMI with rs2237892, rs671, and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed 8 loci at the genome-wide significance level (P<5.0x10-8) and an additional 14 at P<1.0x10-3 with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.
    Date: 2014-10
    Relation: Human Molecular Genetics. 2014 Oct;23(20):5492-5504.
    Link to: http://dx.doi.org/10.1093/hmg/ddu248
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0964-6906&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000343202400016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84964314917
    Appears in Collections:[熊昭] 期刊論文
    [吳易謙] 期刊論文

    Files in This Item:

    File Description SizeFormat
    PUB24861553.pdf1496KbAdobe PDF617View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback