國家衛生研究院 NHRI:Item 3990099045/8026
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12190/12972 (94%)
造訪人次 : 1060393      線上人數 : 433
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    主頁登入上傳說明關於NHRI管理 到手機版
    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8026


    題名: Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
    作者: Wen, W;Zheng, W;Okada, Y;Takeuchi, F;Tabara, Y;Hwang, JY;Dorajoo, R;Li, H;Tsai, FJ;Yang, X;He, J;Wu, Y;He, M;Zhang, Y;Liang, J;Guo, X;Sheu, WH;Delahanty, R;Kubo, M;Yamamoto, K;Ohkubo, T;Go, MJ;Liu, JJ;Gan, W;Chen, CC;Gao, Y;Li, S;Lee, NR;Wu, C;Zhou, X;Song, H;Yao, J;Lee, IT;Long, J;Tsunoda, T;Akiyama, K;Takashima, N;Cho, YS;Ong, RT;Lu, L;Chen, CH;Tan, A;Rice, TK;Adair, LS;Gui, L;Allison, M;Lee, WJ;Cai, Q;Isomura, M;Umemura, S;Kim, YJ;Seielstad, M;Hixson, J;Xiang, YB;Isono, M;Kim, BJ;Sim, X;Lu, W;Nabika, T;Lee, J;Lim, WY;Gao, YT;Takayanagi, R;Kang, DH;Wong, TY;Hsiung, CA;Wu, IC;Juang, JM;Shi, J;Choi, BY;Aung, T;Hu, F;Kim, MK;Wang, TD;Shin, MH;Ji, BT;Lee, YH;Young, TL;Shin, DH;Chun, BY;Cho, MC;Han, BG;Hwu, CM;Assimes, TL;Absher, D;Yan, X;Kim, E;Kuo, JZ;Kwon, S;Taylor, KD;Chen, YD;Rotter, JI;Qi, L;Zhu, D;Wu, T;Mohlke, KL;Gu, D, .;et al.
    貢獻者: Division of Biostatistics and Bioinformatics;Division of Geriatric Research
    摘要: Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and approximately 2.5 million genotyped or imputed SNPs among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488 to 47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P=9.29x10-13), ALDH2/MYL2 (rs671, P=3.40x10-11; rs12229654, P=4.56x10-9), ITIH4 (rs2535633, P=1.77x10-10), and NT5C2 (rs11191580, P=3.83x10-8) genes. The association of BMI with rs2237892, rs671, and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed 8 loci at the genome-wide significance level (P<5.0x10-8) and an additional 14 at P<1.0x10-3 with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.
    日期: 2014-10
    關聯: Human Molecular Genetics. 2014 Oct;23(20):5492-5504.
    Link to: http://dx.doi.org/10.1093/hmg/ddu248
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0964-6906&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000343202400016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84964314917
    顯示於類別:[熊昭] 期刊論文
    [吳易謙] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB24861553.pdf1496KbAdobe PDF618檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋