國家衛生研究院 NHRI:Item 3990099045/8028
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    题名: Androgen receptor, ccl2, and epithelial-mesenchymal transition: A dangerous affair in the tumor microenvironment
    作者: Lin, WJ;Izumi, K
    贡献者: Immunology Research Center
    摘要: High levels of chemokine (C-C motif) ligand 2 (CCL2) promote the metastatic dissemination of prostate cancer by recruiting macrophages to neoplastic lesions. We have recently discovered that inhibiting the androgen receptor (AR) in prostate cancer cells or tumor-infiltrating macrophages results in the upregulation CCL2 and promotes disease progression by activating signal transducer and activator of transcription 3 (STAT3) and by favoring the epithelial-to-mesenchymal transition. Our results indicate that the sole inhibition of AR as a therapeutic intervention against prostate cancer is intrinsically destined to failed.
    日期: 2014-01
    關聯: OncoImmunology. 2014 Jan;3(2):Article number e27871.
    Link to: http://dx.doi.org/10.4161/onci.27871
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2162-402X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000339953700006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84899096925
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