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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/8033
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| Title: | The use of ADSCs as a treatment for chronic stroke |
| Authors: | Chan, TM;Harn, HJ;Lin, HP;Chiu, SC;Lin, PC;Wang, HI;Ho, LI;Chuu, CP;Chiou, TW;Hsieh, AC;Chen, YW;Ho, WY;Lin, SZ |
| Contributors: | Institute of Cellular and Systems Medicine |
| Abstract: | Stroke is one of the disorders for which clinically effective therapeutic modalities are most needed, and numerous ways have been explored to attempt to investigate their feasibilities. However, ischemic- or hemorrhagic-induced inflammatory neuron death causes irreversible injuries and infarction regions, and there are currently no truly effective drugs available as therapy. It is therefore urgent to be able to provide a fundamental treatment method to regenerate neuronal brain cells, and therefore, the use of stem cells for curing chronic stroke could be a major breakthrough development. In this review, we describe the features and classification of stroke and focus on the benefits of adipose tissue-derived stem cells and their applications in stroke animal models. The results show that cell-based therapies have resulted in significant improvements in neuronal behaviors and functions through different molecular mechanisms, and no safety problems have so far arisen after transplantation. Further, we propose a clinical possibility to create a homing niche by reducing the degree of invasive intracerebroventricular transplantation and combining it with continuous intravenous administration to achieve a complete cure. |
| Date: | 2014-04 |
| Relation: | Cell Transplantation. 2014 Apr;23(4-5):541-547. |
| Link to: | http://dx.doi.org/10.3727/096368914x678409 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0963-6897&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000333884900015 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84900412710 |
| Appears in Collections: | [褚志斌] 期刊論文
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| ISI000333884900015.pdf | | 93Kb | Adobe PDF | 451 | View/Open |
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