國家衛生研究院 NHRI:Item 3990099045/8079
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8079


    Title: Hyperuricemia and incident atrial fibrillation in a normotensive elderly population in Taiwan
    Authors: Chuang, SY;Wu, CC;Hsu, PF;Chen, RCY;Liu, WL;Hsu, YY;Pan, WH
    Contributors: Division of Health Services and Preventive Medicine
    Abstract: Background and aim：Atrial fibrillation (AF) is an important cardiovascular disease in the elderly. The association between hyperuricemia and AF is unclear. Therefore, we aimed to investigate the prospective relationship between uric acid and development of AF in a nationally representative cohort of elderly people. Methods and results： A total of 1485 elderly people (age ≥ 65 yrs) from the Elderly Nutrition and Health Survey in Taiwan (1999–2000) were without AF on “electrocardiography” at baseline. Incident AF events (International Classification of Diseases, Ninth Revision, Clinical Modification, ICD-9-CM: 427.31) were identified using data from the National Health Insurance Dataset. Hyperuricemia was defined as levels of uric acid >7.0 mg/dL in men and 6.0 mg/dL in women. A Cox proportional hazards model was used to evaluate the association between hyperuricemia and incident AF. The follow-up period was from 1999 to 2000 to 2008. During the follow-up period (median: 9.16 yrs), 90 AF events occurred (44 in men and 46 in women). Older age, elevated systolic blood pressure, being an ex-smoker, and high uric acid were positively associated with incident AF. Hyperuricemia was positively associated with incident AF in normotensive (age-adjusted hazard ratio (HR): 2.65 and 95% confidence intervals: 1.05–6.69), but not in (1.20:0.74–1.94) hypertensive individuals (systolic blood pressure ≥130 or diastolic blood pressure ≥85 or using hypertensive medicine). A significant association between hyperuricemia and AF (3.78; 1.24–11.59) remained after adjusting for other potential confounders among normotensive older persons. Conclusion： Hyperuricemia is associated with the development of AF in elderly people with normal blood pressure.
    Date: 2014-09
    Relation: Nutrition, Metabolism and Cardiovascular Diseases. 2014 Sep;24(9):1020-1026.
    Link to: http://dx.doi.org/10.1016/j.numecd.2014.03.012
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0939-4753&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000341315500013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84929048366
    Appears in Collections:[Wen-Harn Pan] Periodical Articles
    [Shao-Yuan Chuang] Periodical Articles

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