國家衛生研究院 NHRI:Item 3990099045/8084
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 917451      在线人数 : 1420
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8084


    题名: Functional effects of TGF-beta 1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma
    其它题名: Functional effects of TGF-β 1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma
    作者: Gao, PS;Zhou, YF;Xian, LL;Li, CJ;Xu, T;Plunkett, B;Huang, SK;Wan, M;Cao, X
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: Mesenchymal stem cells (MSCs) have been suggested to participate in immune regulation and airway repair/remodeling. TGF-beta 1 is critical in the recruitment of stem/progenitor cells for tissue repair, remodeling, and cell differentiation. In this study, we sought to investigate the role of TGF-beta 1 in MSC migration in allergic asthma. We examined nestin expression (a marker for MSCs) and TGF-beta 1 signaling activation in airways in cockroach allergen extract (CRE)-induced mouse models. Compared with control mice, there were increased nestin(+) cells in airways and higher levels of active TGF-b1 in serum and p-Smad2/3 expression in lungs of CRE-treated mice. Increased activation of TGF-beta 1 signaling was also found in CRE-treated MSCs. We then assessed MSC migration induced by conditioned medium from CRE-challenged human epithelium in air/liquid interface culture in Transwell assays. MSC migration was stimulated by epithelial-conditioned medium, but was significantly inhibited by either TGF-beta 1-neutralizing Ab or T beta R1 inhibitor. Intriguingly, increased migration of MSCs from blood and bone marrow to the airway was also observed after systemic injection of GFP(+) MSCs and from bone marrow of Nes-GFP mice following CRE challenge. Furthermore, TGF-beta 1-neutralizing Ab inhibited the CRE-induced MSC recruitment, but promoted airway inflammation. Finally, we investigated the role of MSCs in modulating CRE-induced T cell response and found that MSCs significantly inhibited CRE-induced inflammatory cytokine secretion (IL-4, IL-13, IL-17, and IFN-g) by CD4(+) T cells. These results suggest that TGF-beta 1 may be a key promigratory factor in recruiting MSCs to the airways in mouse models of asthma.
    日期: 2014-05
    關聯: Journal of Immunology. 2014 May;192(10):4560-4570.
    Link to: http://dx.doi.org/10.4049/jimmunol.1303461
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-1767&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000335973600013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84901261243
    显示于类别:[黃嘯谷] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI000335973600013.pdf1776KbAdobe PDF459检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈