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http://ir.nhri.org.tw/handle/3990099045/8115
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| Title: | Outcomes and predictive factors of prostate cancer patients with extremely high prostate-specific antigen level |
| Authors: | Izumi, K;Lin, WJ;Miyamoto, H;Huang, CK;Maolake, A;Kitagawa, Y;Kadono, Y;Konaka, H;Mizokami, A;Namiki, M |
| Contributors: | Immunology Research Center |
| Abstract: | Purpose Prostate-specific antigen (PSA) is a useful biomarker of prostate cancer (PCa). High-risk localized PCa is defined using T stage, Gleason score (GS), and PSA. However, PSA level defining high-risk PCa is at most 20 ng/mL. In PCa patients with high PSA, it is unclear whether PSA itself can be a prognostic factor. Methods Of 642 patients who were diagnosed as PCa, 90 patients with PSA > 100 ng/mL were retrospectively analyzed. Patients were divided into three groups according to PSA level: very high (>1,000 ng/mL), moderately high (200-1,000 ng/mL), and slightly high (100-200 ng/mL). Results There were no significant differences in overall survival or PCa-specific survival (PCaSS) among the three groups. Regardless of PSA level, high M stage and GS significantly reduced PCaSS. When the risk classification was made using M stage and GS (high risk = M1 and GS ≥ 9, low risk = M0 and GS < 9, and intermediate risk = others), PCaSS was significantly different among high-, intermediate-, and low-risk groups with 5-year survival rates of 58.2, 80.6, and 100 %, respectively. Although there were no differences in treatment performed during the castration-resistant stage, patients undergoing alternative anti-androgen and zoledronic acid treatment had better PCaSS after being castration-resistant. Conclusions As PSA could not be a prognostic factor in PCa patients with high PSA > 100 ng/mL, the novel risk classification using M stage and GS may help clinicians to predict PCaSS and to plan follow-up schedules after diagnosis. |
| Date: | 2014-08 |
| Relation: | Journal of Cancer Research and Clinical Oncology. 2014 Aug;140(8):1413-1419. |
| Link to: | http://dx.doi.org/10.1007/s00432-014-1681-8 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0171-5216&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000340558200017 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84904331571 |
| Appears in Collections: | [林文傑] 期刊論文
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Files in This Item:
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Size | Format | |
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| SCP84901580865.pdf | | 1225Kb | Adobe PDF | 595 | View/Open |
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