國家衛生研究院 NHRI:Item 3990099045/8120
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    题名: An in vivo implantable dual-functional microdevice for simultaneous photoenergy transmission/detection and neurochemical delivery/analysis
    作者: Lo, LW;Huang, SHY;Tsai, PJ;Lo, SW;Yang, CS
    贡献者: Center for Nanomedicine Research;Division of Medical Engineering Research
    摘要: An implantable and dual functional needle-type microprobe (500 μm o.d.) composed of a microdialysis probe and 13 optical fibers was designed and constructed (combomicroprobe). This combo-microprobe is capable of in vivo neurochemical delivery/analysis and photoenergy transmission /detection. The combo-microprobe was implanted into anesthetized rat brains and was used to simultaneously observe the cerebral ischemiainduced increase in extracellular glutamate concentration, which was performed by the microdialysis perfusion and analysis; and the increase in blood brain barrier permeability, which was performed by the optical fibers to monitor the extravasated fluorescent nanospheres. This combo-microprobe can be applied to various in vivo biomedical investigations in the future.
    日期: 2005-10
    關聯: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005. 2005 Oct;1:1032-1034.
    Link to: http://small.buffalo.edu/data/MicroTAS2005_Final_Brochure.pdf
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84902466716
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