國家衛生研究院 NHRI:Item 3990099045/8123
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    题名: Interpretable prediction of non-genotoxic hepatocarcinogenic chemicals
    作者: Tung, CW;Jheng, JL
    贡献者: National Environmental Health Research Center
    摘要: The assessment of non-genotoxic hepatocarcinogenicity of chemicals relies on time-consuming rodent bioassays. The development of alternative methods for non-genotoxic hepatocarcinogenicity could help the identification of potential hepatocarcinogenic chemicals. This study evaluated four types of features for the interpretable prediction of non-genotoxic hepatocarcinogenic chemicals including chemical-chemical interactions (CCI), chemical-protein interactions (CPI), chemical descriptors (QSAR) and gene expression profiles (TGx). Based on the results of decision tree classifiers, the CPI-based features perform best with independent test accuracies of 90% and 86% for interaction scores from combined scores and databases, respectively. Informative features were identified and analyzed to give insights into the non-genotoxic hepatocarcinogenicity of chemicals. The difference between CPI scores and gene expression profiles for the identified important proteins shows that CPI could play more important roles in non-genotoxic hepatocarcinogenicity.
    日期: 2014-12
    關聯: Neurocomputing. 2014 Dec;145:68-74.
    Link to: http://dx.doi.org/10.1016/j.neucom.2014.05.073
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0925-2312&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000342248100010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84906935725
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