 |
English
|
正體中文
|
简体中文
|
Items with full text/Total items : 12500/13673 (91%)
Visitors : 2843110
Online Users : 381
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/8173
|
| Title: | Genotypes and virulence in serotype K2 Klebsiella pneumoniae from liver abscess and non-infectious carriers in Hong Kong, Singapore and Taiwan |
| Authors: | Lin, JC;Koh, TH;Lee, N;Fung, CP;Chang, FY;Tsai, YK;Ip, M;Siu, LK |
| Contributors: | Division of Infectious Diseases |
| Abstract: | In Klebsiella pneumoniae liver abscess (KP-LA), K. pneumoniae K2 is the most frequently isolated serotype after K1, but this serotype has been much less studied. In the present study, the molecular types sequences type (MLST) of serotype K2 isolates from three different regions in Asia were identified and the virulence of these isolates was investigated. Eight different MLSTs were found among 26 isolates (ST 65, 66, 86, 373, 374, 375, 380, and 434). There were two major MLST groups, ST-65-like (42%) and ST86-like (46%). No isolates contained allS while all isolates contained rmpA. The prevalence of aerobactin gene and kfu were 25/26 (96%) and 3/26 (11.5%) respectively. Although liver abscess isolates were generally more resistant (11/15 isolates) to serum killing, there was no specific distribution of serum killing resistant or susceptible ST types between stool carriage and liver abscess isolates. Neutrophil phagocytosis showed that the liver abscess and carriage isolates varied in their susceptibility to phagocytosis. Strains with resistance to both neutrophil phagocytosis and serum killing were generally hypervirulent with lethality at LD50 < 103 colony forming units by intraperitoneal injection. In conclusion, Anti-phagocytosis and resistance to serum killing are two parameters that most predict hyperviurlence in serotype K2 isolates. Unlike serotype K1 KP-LA that mainly belong to ST-23, ST-65-like and -86-like are the two major MLST types among serotype K2 isolates from Singapore, Hong Kong and Taiwan. |
| Date: | 2014-06-12 |
| Relation: | Gut Pathogens. 2014 Jun 12;6:Article number 21. |
| Link to: | http://dx.doi.org/10.1186/1757-4749-6-21 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1757-4749&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000338585300002 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84903791542 |
| Appears in Collections: | [蕭樑基] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| ISI000338585300002.pdf | | 334Kb | Adobe PDF | 491 | View/Open |
|
All items in NHRI are protected by copyright, with all rights reserved.
|
