國家衛生研究院 NHRI:Item 3990099045/8205
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 916600      在线人数 : 1481
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8205


    题名: Overexpression of DPP4 is a poor prognostic factor for patients with urothelial carcinoma of the upper urinary tract and urinary bladder
    作者: Liang, PI;Wu, WJ;Huang, CN;Li, CC;Ke, HL;Li, WM;Yeh, HC;Li, CF;Lee, YY;Lin, HH;Yeh, BW;Hwang, SJ
    贡献者: National Institute of Cancer Research
    摘要: Background：Dipeptidyl peptidase-4 (DPP4), also known as CD26, is an enzyme that cleaves a diversity of protein that contains proline or analine, including chemokines, growth factors, and neuropeptide. Different DPP4 expression status has been observed in malignant tumours, including colon, renal, and ovarian carcinoma. Data mining of the published dataset (GSE31684) identified that DPP4 is significantly upregulated in urothelial carcinoma of the urinary bladder. We therefore analysed the association of DPP4 expression and outcome in our well-characterised cohort of urothelial carcinoma. Methods: Laser capture microdissection coupled with real-time qRT-PCR was used to evaluate DPP4 transcript level in 20 urothelial carcinomas of the urinary bladder. DPP4 immunostaining was done on 340 cases of urothelial carcinoma of the upper urinary tract and 295 cases of urothelial carcinoma of the urinary bladder. The expression status of DPP4 was then correlated with various clincopathological factors, disease-specific survival (DSS), and metastasis-free survival (MeFS). Findings: DPP4 mRNA expression was significantly increased in urothelial carcinomas with higher pT status (p < 0.001). In both groups of urothelial carcinomas, increment of DPP4 immunoexpression was significantly associated with advanced pT stage (both p < 0.001), high histological grade (urothelial carcinoma of the upper urinary tract, p = 0.019), lymph node metastasis (urothelial carcinoma of the upper urinary tract,p < 0.001; urothelial carcinoma of the urinary bladder, p = 0.033), vascular invasion (both p < 0.001), perineurial invasion (urothelial carcinoma of the urinary bladder, p = 0.021) and frequent mitosis (urothelial carcinoma of the upper urinary tract, p = 0.003). DPP4 overexpression independently predicted poor DSS (urothelial carcinoma of the upper urinary tract, p = 0.028; urothelial carcinoma of the urinary bladder,p < 0.0001) and MeFS (urothelial carcinoma of the upper urinary tract, p = 0.031; urothelial carcinoma of the urinary bladder, p < 0.0001) in both groups of patients. Interpretation: Our study shows that overexpression of DPP4 is significantly associated with aggressive tumour behaviour and poor outcome. DPP4 may have an important role in tumorigenesis of urothelial carcinoma.
    日期: 2014-05
    關聯: European Journal of Cancer. 2014 May;50(Suppl. 4):e39.
    Link to: http://dx.doi.org/10.1016/j.ejca.2014.03.152
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0959-8049&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000351589200110
    显示于类别:[其他] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    SDO0959804914004249.pdf35KbAdobe PDF517检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈