國家衛生研究院 NHRI:Item 3990099045/8207
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    題名: Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents
    作者: Mehndiratta, S;Chiang, YF;Lai, MJ;Lee, HY;Chen, MC;Kuo, CC;Chang, CY;Chang, JY;Liou, JP
    貢獻者: National Institute of Cancer Research
    摘要: Described herein is the development of a novel series of 7-anilino-indoline-N-benzenesulfonamides, derived from ABT751 (1), as potent anticancer agents. Amongst the synthesized series, compounds 6, 12, 13, and 14 have shown comparable to better anticancer activity on comparing with compound 1. 7-(4-Cyanophenylamino)-1-(4-methoxybenzenesulfonyl)indoline (13) was found to be the most potent one with up to 6 fold better activity against KB, HT29, and MKN45 cancer cell lines with IC50 values of 49.7, 149, and 92nM, respectively. Compound 13 was also found inhibiting multidrug resistant cancer cell lines, blocking cell cycle at G2/M phase, and inhibiting tubulin polymerization. Capillary disruption assay results revealed that compound 13 was able to disrupt formed capillaries in a concentration-dependent manner without affecting cell viability.
    日期: 2014-09
    關聯: Bioorganic and Medicinal Chemistry. 2014 Sep;22(17):4917-4923.
    Link to: http://dx.doi.org/10.1016/j.bmc.2014.06.042
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0968-0896&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000341293300041
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84906935715
    顯示於類別:[張俊彥] 期刊論文
    [郭靜娟] 期刊論文

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