國家衛生研究院 NHRI:Item 3990099045/8210
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    题名: Novel peptides suppress VEGFR-3 activity and antagonize VEGFR-3-mediated oncogenic effects
    作者: Chang, YW;Su, CM;Su, YH;Ho, YS;Lai, HH;Chen, HA;Kuo, ML;Hung, WC;Chen, YW;Wu, CH;Chen, PS;Su, JL
    贡献者: National Institute of Cancer Research
    摘要: Vascular endothelial growth factor receptor 3 (VEGFR-3) supports tumor lymphangiogenesis. It was originally identified as a lymphangiogenic factor expressed in lymphatic endothelial cells. VEGFR-3 was detected in advanced human malignancies and correlated with poor prognosis. Our previous studies show that activation of the VEGF-C/VEGFR-3 axis promotes cancer metastasis and is associated with clinical progression in patients with lung cancer, indicating that VEGFR-3 is a potential target for cancer therapy. In this study, we developed eight peptides targeting VEGFR-3. Two peptides strongly inhibited the kinase activity of VEGFR-3 and suppressed VEGF-C-mediated invasion of cancer cells. Moreover, these peptides abolished VEGF-C-induced drug resistance and tumor initiating cell formation. This study demonstrates the therapeutic potential of VEGFR-3-targeting peptides.
    日期: 2014-05-20
    關聯: Oncotarget. 2014 May 20;5(11):3823-3835.
    Link to: http://dx.doi.org/10.18632/oncotarget.1709
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000339054500033
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84903547377
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