國家衛生研究院 NHRI:Item 3990099045/8233
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    题名: A novel mechanism for acupuncture-induced analgesia: involvement of orexins and endocannabinoids
    作者: Chiou, LC;Chen, YH;Lee, HJ;Wu, YT;Lee, YH;Hwang, LL;Hung, MS;Zimmer, A;Mackie, K
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Here, we reveal a novel analgesic mechanism for electroacupuncture. Low frequency electroacupuncture at the PC6 (Neiguan) acupoint (EA-PC6), but not electro-stimulation at a non-acupoint location (NAP) or needle insertion alone, increased the number of c- Fos expressing-orexin neurons in the lateral hypothalamus and orexin A levels in the ventrolateral periaqueductal gray (vlPAG), and induced antinociception in mice. EA-PC6-induced antinociception was signi ? cantly attenuated by systemic or intra-vlPAG pretreatment with the OX1 or CB1 receptor antagonist, and by intra-vlPAG inhibition of the synthesizing enzyme of 2-arachidonoylglycerol (2-AG), but not by systemic pretreatment with opioid receptor antagonists. EA-PC6 elicited a weak antinociceptive effect in Cnr1 / mice. EA-PC6-induced antinociception is not a phenomenon of stress-induced analgesia since EA-PC6 decreased the plasma corticosterone level. These ? ndings suggest that EA-PC6 activates hypothalamic orexin neurons, releasing orexins to induce analgesia through an opioid-independent but CB1 receptor-dependent cascade mediated by an OX1 receptor-initiated 2-AG retrograde disinhibition mechanism 1 in the vlPAG.
    日期: 2014-08
    關聯: Journal of Neurochemistry. 2014 Aug;130(Suppl. s1):38.
    Link to: http://dx.doi.org/10.1111/jnc.12777
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-3042&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000339492800080
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