國家衛生研究院 NHRI:Item 3990099045/8251

NHRI > National Institute of Infectious Diseases and Vaccinology > Ih-Jen Su(2002-2015) > Periodical Articles > Item 3990099045/8251

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Title:	Early dexamethasone treatment exacerbates enterovirus 71 infection in mice
Authors:	Shen, FH;Shen, TJ;Chang, TM;Su, IJ;Chen, SH
Contributors:	Division of Infectious Diseases
Abstract:	Enterovirus 71 (EV71) infection can induce encephalitis. Overt immune responses is suspected to cause severe symptoms, so anti-inflammatory agents, corticosteroids have been recommended for treatment. However, one clinical study reported that treatment with glucocorticoids, dexamethasone (Dex) exacerbates disease severity. Here we investigated Dex treatment on EV71 infection using the murine model and found that both long-term (14-day) and short-term (4-day) Dex treatment starting from 1 or 3 days postinfection increased the mortality and disease severity of infected mice. Dex treatment starting from 4 or 8 days postinfection did not affect mouse mortality and disease severity. Early Dex treatment starting from 1 day postinfection caused atrophy and enhanced apoptosis in lymphoid organs to decrease the numbers of lymphocytes (CD4+ T cells, CD8+ T cells, and CD19+ B cells) and to increase viral loads in infected tissues of mice. Our results demonstrate that Dex treatment has no beneficial effect on EV71 infection.
Date:	2014-09
Relation:	Virology. 2014 Sep;464-465(1):218-227.
Link to:	http://dx.doi.org/10.1016/j.virol.2014.07.021
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0042-6822&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000341550000023
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84905398202
Appears in Collections:	[Ih-Jen Su(2002-2015)] Periodical Articles

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